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Paediatric research studies

The purpose of the study is to identify children and adults newly diagnosed with type 1 diabetes and their brothers and sisters (siblings), who might be interested in taking part in future diabetes research studies. We want to collect information and blood samples from these people to understand more about the development and progression of type 1 diabetes, and to help find suitable trials of new treatments or other studies into diabetes that they might want to take part in. When we find suitable trials or diabetes studies we will write to the eligible people to ask if they would be interested in taking part.

Children with nephrotic syndrome suffer from disease relapses, where the protein in the urine returns. When these occur, treatment with high dose prednisolone is commenced and this may be associated with a number of side-effects, such as a puffy face, high blood pressure or changes in mood. For this reason, every effort is made to prevent relapses from happening. This generally involves the use of either low dose every other day prednisolone, or other drugs such as levamisole, ciclosporin or mycophenolate mofetil.

It is well know that relapses may be caused by upper respiratory tract infection (URTI– the common cold). The purpose of this study is to see whether giving a six day course of daily prednisolone when children develop an URTI prevents relapses from developing: we will study this in a large population of UK children with relapsing nephrotic syndrome.

The HARMONIE Research Study is enrolling newborn babies to babies 12 months old. It follows on from other research studies which have been completed and is looking at how strongly babies can be protected from serious illness due to RSV infection (respiratory syncytial virus) by giving them a single antibody dose.

Respiratory Syncytial Virus (RSV) is a leading cause of hospitalisations. Mostly it causes a mild illness but, even previously fit and healthy babies can be seriously affected requiring hospital stays and even intensive care for a few. In the UK about 1 in 25 of all children born each year are hospitalised with a RSV infection.

Warrington and Halton Teaching Hospitals are part of a study looking at whether a one-off injection of Nirsevimab will protect babies from being admitted with RSV bronchiolitis.

To learn more about this study and whether it may be an option for your baby, please visit RSVHarmonieStudy.com or if you would like to talk to one of our research nurses before enrolling call the Halton Clinical Research Unit on 01928 753303.