Rheumatology and Orthopaedic studies
Dr Salih is the lead consultant for Rheumatology research with commercial and academic studies in Rheumatoid Arthritis, Ankylosing Spondylitis, Giant Cell Arteritis and Systemic Lupus Erythematosus.
Current studies include:
The BSR Rheumatoid Arthritis Register is a long term prospective observation cohort study that was set up in 2001 to monitor the long-term safety and efficacy of biologic therapy in participants with rheumatoid arthritis.
The British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR-AS) tracks the progress of patients with Ankylosing Spondylitis who are taking biologic therapy.
This register is a collaboration between the University of Aberdeen and the British Society for Rheumatology. Consultant rheumatologists in the UK who prescribe anti-TNF therapy for patients with Ankylosing Spondylitis can participate in the register.
Run by the University of Leeds, the purpose of the study is to find out more about the causes of giant cell arteritis (GCA, sometimes called temporal arteritis) and polymyalgia rheumatica (PMR). We also would like to find out how to predict whether a person with one of these conditions will be more severely affected or only mildly affected. We hope that the findings of this research will help other patients with this condition in the future by leading to the development of better treatments for this disease, with fewer side-effects than the steroid treatment that is currently standard.
The Genetics of Ankylosing Spondylits
It is known that AS can ‘run’ in families and that it has a strong genetic or inherited element, probably involving at leastthirty different genes. Using modern laboratory techniques it should now be possible to identify most of the important genes involved in diseases like AS. Indeed, our research programme has already identified several “AS” genes that have given us a much clearer understanding of the processes by which AS develops. Our goal is to identify as many of these genes as possible so that we can understand the disease better and develop better ways of diagnosing and treating it.
Please contact the research nurse on 01925 662946 if you would like any more information about research studies in Rheumatology.
Mr Stables is the principle investigator involved in national multicentre orthopaedic studies here at Warrington & Halton.
The specialities currently covered are:
- Knee replacement
- Wrist fractures
PATH-2 STUDY: Platelet Rich Plasma in Achilles Tendon Healing - A study looking at the best way to heal your torn Achilles tendon
The PATH-2 Study compares usual non-surgical plaster cast treatment for a torn Achilles tendon to a new treatment in which Platelet Rich Plasma (PRP) is injected into the torn tendon, in addition to receiving usual cast treatment. The aim is to see if PRP improves healing.
A new treatment has been developed, using an injection of ‘Platelet Rich Plasma’ (PRP). The aim of PRP is to improve the repair of the tendon. PRP aims to take advantage of the body’s normal healing abilities to help repair injuries. The cells in PRP contain special growth and regeneration factors that stimulate the body’s healing response in the injured tendon.
PRP is made using a sample of a person’s own blood. The blood sample is taken using a needle and syringe. The blood is spun in a machine called a centrifuge and after spinning what remains is the platelet rich plasma.
The person’s own PRP is then injected into their Achilles tendon at the site if the injury. A local anaesthetic is given at the tendon area before the PRP injection to help ease any discomfort.
The PRP injection is applied immediately prior to the cast, splint or boot.
PRP has been shown to accelerate healing in a small group of patients. A larger study (the PATH-2 Study), is now underway to look into this further to improve the evidence as to whether this is an effective treatment.
Please contact the research nurses on 01925 662946 if you would like any more information about research studies in Orthopaedics.
Consultant Led Research
Mr Pradhan, Orthopaedic Consultant, is running his own clinical trial into a new technique for performing knee replacements. Find out more by clicking here.