Warrington and Halton Hospitals

Paediatric research studies


ADDRESS2

An incident and high risk type 1 diabetes cohort - After Diagnosis Diabetes Research Support System-2 (ADDRESS-2)

The purpose of the study is to identify children and adults newly diagnosed with type 1 diabetes and their brothers and sisters (siblings), who might be interested in taking part in future diabetes research studies. We want to collect information and blood samples from these people to understand more about the development and progression of type 1 diabetes, and to help find suitable trials of new treatments or other studies into diabetes that they might want to take part in. When we find suitable trials or diabetes studies we will write to the eligible people to ask if they would be interested in taking part.


PREDNOS2

Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.

Children with nephrotic syndrome suffer from disease relapses, where the protein in the urine returns. When these occur, treatment with high dose prednisolone is commenced and this may be associated with a number of side-effects, such as a puffy face, high blood pressure or changes in mood. For this reason, every effort is made to prevent relapses from happening. This generally involves the use of either low dose every other day prednisolone, or other drugs such as levamisole, ciclosporin or mycophenolate mofetil.

It is well know that relapses may be caused by upper respiratory tract infection (URTI– the common cold). The purpose of this study is to see whether giving a six day course of daily prednisolone when children develop an URTI prevents relapses from developing: we will study this in a large population of UK children with relapsing nephrotic syndrome.


Torpedo

People with Cystic Fibrosis are at risk of developing infection in their lungs. If this should happen then a common cause of infection can be a bacteria or germ called Pseudomonas aeruginosa. Usually when this bacteria is first found in the sputum or cough swab patients are treated with antibiotics to get rid of (eradicate) the bacteria. There is a choice of treatment that can then be used to eradicate the bacteria – either antibiotics taken by mouth (orally) or given directly into the vein usually in the arm or the back of the hand (intravenously, IV), each given in association with three months of inhaled antibiotic treatment through a machine called a nebuliser which allows you to inhale the medication as a mist directly into your lungs. It is generally accepted that these treatments are essential to try to get rid of the Pseudomonas.

However, we do not know for sure which of these treatments is the best to help get rid of this type of infection.The only way to find out which of these two treatments is the most helpful is to compare the two treatments in adults and children with Cystic Fibrosis (CF), in a radomised controlled trial.


SANAD2

A pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide

versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II).

Epilepsy is a common neurological (brain) disorder. Approximately 2-3% of the population will be given a diagnosis of epilepsy by time they reach 60.

A number of new have been approved to treat epilepsy in the United Kingdom in the past few years. These drugs have been shown in research studies to prevent seizures and to be safe. There is as yet, however, no good evidence as to whether they are better at treating epileptic seizures or safer than the standard drugs that have been used for many years.

In this research study – called SANAD-II – we will compare the standard and new antiepileptic drugs to identify which drugs are the most effective and which ones make the best use of NHS resources.


Humox

Normally, our airways add water to the air that we breathe. This makes it easier to keep them open. In an acute asthma attack, the muscles in the airway walls tighten and the airway lining becomes inflamed and starts to swell. This causes them to narrow, making it difficult to breathe.

As part of your child’s asthma treatment, they are being given oxygen via a face-mask. In most hospitals around the country, oxygen comes out of the wall, cold and dry. We would like to find out whether adding water and warming the oxygen reduces the amount of time that children need this treatment, and how long they spend in hospital. Our aim is to ensure we are giving children with asthma the best care we can.


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